Leaky Gut and Autoimmune Diseases - Research
Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune
pathogenesis.
Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease
Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs. Oral immune therapy is a method of systemic immune modulation via alteration of the gut immune system. It uses the inherit ability of the innate system of the gut to redirect the systemic innate and adaptive immune responses. Oral immune therapy is an attractive clinical approach to treat autoimmune and inflammatory disorders. It can induce immune modulation without immune suppression, has minimal toxicity and is easily administered.
Malnutrition and Gut Microbiota in Children
Malnutrition remains a global crisis, especially for young children. While lack of food and infections are key drivers, emerging research shows the gut microbiota also plays a major role. Diet strongly influences the development of gut bacteria, which in turn affects a child’s nutritional status. Breastfeeding shapes the infant gut by promoting beneficial bifidobacteria, while the introduction of solid foods increases microbial diversity. It is also becoming evident that initial feeding practices and their resulting impact on the gut microbiota of infants have both short- and long-term effects on health throughout life. These early feeding practices have lasting effects on gut health and may impact a child’s risk of malnutrition.