About GcMaf
GcMAF, or Gc protein-derived Macrophage Activating Factor, is an immunotherapy developed in Japan by Saisei Mirai clinics in collaboration with researchers from the University of Tokushima. Beginning in 1992, they advanced GcMAF into a second-generation form by 2011, enhancing its concentration, stability, and activity. Produced in Saisei Mirai’s sterile Cell Processing Center, this version is 10–20 times more potent than earlier forms and has been safely administered to over 1,000 patients. It activates macrophages to combat diseases like cancer, chronic fatigue syndrome, and autism spectrum disorders. Clinical studies show minimal side effects, typically limited to mild, short-term reactions in rare cases.
NATURAL ORAL IMMUNE THERAPY – GCMAF
GcMAF (Gc Protein-derived Macrophage Activating Factor) occurs naturally in our bodies and instructs macrophages to destroy cancerous cells and foreign invaders by activating them. Macrophages (Greek: big eaters) are cells originating from monocytes, a type of white blood cell found in the body. Macrophages function in both non-specific defense (innate immunity) as well as help initiate specific defense mechanisms (adaptive immunity) of vertebrate animals.
Their role is to phagocytize (engulf and then digest) cellular debris and pathogens, either as stationary or as mobile cells. They also stimulate lymphocytes and other immune cells to respond to pathogens.
They are specialized phagocytic cells that attack foreign substances, infectious microbes and cancer cells through destruction and ingestion.
Where are macrophages found in the body? Macrophages and other phagocytes are found in the following locations in the body:
| Main location | Types of phagocytes |
| Skin * | macrophages, resident Langerhans cells, dendritic cells, mast cells |
| Gut and intestinal Peyer’s patches | macrophages |
| Lungs | macrophages, monocytes, mast cells, dendritic cells |
| Blood | neutrophils, monocytes |
| Bone marrow | macrophages, monocytes, sinusoidal cells, lining cells |
| Connective tissue | macrophages, monocytes, dendritic cells, histiocytes |
| Lymphoid tissue | macrophages, monocytes, dendritic cells |
| Spleen | macrophages, monocytes, sinusoidal cells |
| Thymus | macrophages, monocytes |
For any infectious or parasitic disease to start, it is always a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.
Clinical Aspects of Immunology and Biochem J.
The spleen holds 50 percent of both macrophages and monocytes. Following GcMAF treatment, the direction of blood flow to the spleen increases along with other biological components that stimulate a healthy immune system. The mouth and throat contain specific immunological lymphoid tissue highly concentrated with macrophages. Mixing colostrum powder with water and swishing it around your mouth for 15 to 20 minutes can activate macrophages and help you absorb immunoglobins sublingually. Critical neural macrophages are microglia and are found in the brain and spine. Microglia supports the immune system by defending against invasive threats to the central nervous system which create damage. Microglia is one of the central nervous system’s first lines of defense. Many substances can activate macrophages, some probiotics are able to independantly activate macrophages. Enzymes of certain strains of microorganisms contained in yogurt and kefir are able to convert milk Gc-protein into active DBP-MAF.
A true bio active – Immune For Life
Bovine colostrum contains leukocytes, which are cells that may be important for passive immunity. The types of leukocytes in colostrum include:
Macrophages: The most common cell type, making up 50–90% of colostrum leukocytes.
T-lymphocytes: The second most common cell type, making up about 16% of colostrum leukocytes.
B-lymphocytes: A small number of B-lymphocytes are present, usually less than 5%.
Polymorphonuclear cells: Mostly neutrophils, these cells make up 3–6% of colostrum leukocytes.
Epithelial cells: These cells make up 2–15% of colostrum leukocytes.
The number of leukocytes in colostrum can vary depending on the cow’s age, breed, health, and immune status.
Colostrum also contains other bioactive components, such as immunoglobulins, growth factors, vitamins, and hormones.