Why Mammal Milk and What Is Phagocytosis?

Mammal milk plays a significant role in boosting immune functions, particularly in older adults. Research has shown that whole fat mammal milk can help restore immune cell function, especially in the elderly, by enhancing phagocytosis. Phagocytosis is the process where immune cells “eat” and break down harmful bacteria or infected cells, helping the body resist infections. Strains of lactic acid bacteria, such as acidophilus, also have been shown to enhance phagocytosis.

A problem with the body’s autophagic mechanism (a process where cells clean up and recycle damaged components) can lead to chronic intestinal inflammation, as seen in conditions like Inflammatory Bowel Disease (IBD).

Milk is not just an immune booster; it’s packed with essential nutrients like proteins, amino acids, minerals, and vitamins, which all work together to support health. Some key components of milk, such as oleic acid (a fat), cysteine and methionine (amino acids), galactose (a sugar), and lactalbumin (a protein), have been found to play crucial roles in enhancing immune function. These nutrients help support immune therapy and aid in the production of immune-enhancing substances like GcMAF (a molecule used in immune therapy).

Whole fat milk is particularly useful as a prebiotic or synbiotic when combined with probiotics, which is why products like yogurt, kefir, and buttermilk are popular for supporting digestive and immune health.


The Impact of Malnutrition

Research into chronic malnutrition shows a variety of negative effects, including:

 

    • Failure to thrive

    • Growth retardation

    • Diarrhea

    • Decreased appetite

    • Eye inflammation (which can lead to a serious eye condition called xerophthalmia, often due to vitamin A deficiency)

Kwashiorkor, a severe protein malnutrition disease, occurs when infants are weaned off breast milk and switched to a diet low in protein, often resulting in symptoms like edema (swelling), hair loss, skin issues, diarrhea, and, in severe cases, brain damage.

Interestingly, research shows that malnutrition can disrupt the microbiome (the community of bacteria in the gut), which makes it harder to recover from malnutrition. This lack of healthy gut bacteria contributes to the ongoing nutritional deficiencies, which cannot be fixed with current treatments alone.


Whey Protein and Glutathione

Whey protein is unique because it can boost glutathione (GSH) levels in the body. Glutathione is a powerful antioxidant that protects cells from free radical damage, infections, toxins, pollution, and UV rays. It’s an essential part of the body’s defense system. People with conditions like cancer or chronic fatigue syndrome often have low levels of glutathione, so consuming whey protein may help improve their immune function.

The sulfur-containing amino acids cysteine and methionine, which are found in whey, are key for producing glutathione. In fact, whey protein is considered one of the most effective ways to increase glutathione levels in the body.


Milk and Cancer Protection

In 1995, researchers discovered that a component of human milk, called casein, could block harmful bacteria from sticking to cells and even selectively kill cancer cells, including lung cancer cells. This discovery led to the identification of a molecule called HAMLET (Human α-lactalbumin Made Lethal to Tumor cells), which can kill a variety of cancer cells, including those from carcinomas and melanomas.

Interestingly, BAMLET, which is derived from bovine milk, has shown even more potent effects than HAMLET in fighting cancer. The key to this power lies in oleic acid (a fat) binding with α-lactalbumin, making it toxic to cancer cells. Research suggests that both HAMLET and BAMLET work by triggering cancer cells to break down, a process similar to phagocytosis.


Oleic Acid and Brain Health

Oleic acid, a fatty acid found in high amounts in both breast milk and cow’s milk, is critical for brain health. It helps synthesize myelin, the protective covering around nerves. Myelin is made up of 70% fat, and oleic acid is one of the primary fats involved in its formation. Oleic acid also plays a role in cell signaling, cholesterol regulation, and lipogenesis (the process of creating fat), particularly in the brain.

In addition, oleic acid has shown potential in protecting against Alzheimer’s disease. Research suggests that fermented dairy products, like yogurt and kefir, can reduce brain protein buildup (known as Aβ accumulation) by increasing microglial phagocytosis (the process by which immune cells clear debris) and decreasing inflammation in the brain. This is thought to help prevent neurodegenerative diseases like Alzheimer’s.


Buttermilk and Health Benefits

Buttermilk, the liquid left after churning butter, is a powerful drink for overall health. It has been shown to lower both serum cholesterol and liver cholesterol, as well as reduce high blood pressure. Buttermilk contains unique bioactive molecules that help regulate cell signaling, lipid transport, and metabolism. It is also packed with electrolytes, making it an excellent way to stay hydrated.

Moreover, buttermilk contains high levels of calcium, Vitamin B Complex, and probiotics that support gut health. It is also considered a natural remedy for stomach irritation and helps with digestion.


The Role of Milk in Animal Health

Milk-derived products, like whey protein, have significant benefits for animal health, especially in farm animals. Unlike traditional antibiotics, which can harm both animals and the environment, whey protein boosts the glutathione levels in animals’ livers and other organs, helping to keep them disease-free without the need for medications. This practice has been shown to improve overall animal health and reduce environmental impact by decreasing the use of chemical drugs and antibiotics.


Conclusion

Mammal milk is not just a source of nutrition for infants; it also contains powerful compounds that support immune health, help protect against disease, and improve overall well-being. Whether it’s boosting phagocytosis, fighting cancer, supporting brain health, or helping with conditions like malnutrition, milk and its derivatives like whey and buttermilk have numerous health benefits.

More info:


Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation. Accumulating evidence underlines that milk is a complex signaling and epigenetic imprinting network that promotes stable FoxP3 expression and long-lasting Treg differentiation, crucial postnatal events preventing atopic and autoimmune diseases.

Clin Transl Allergy. 2016 May 12;6:18. doi: 10.1186/
s13601-016-0108-9. eCollection 2016

Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products

Although bioactive compounds in milk and dairy products have been extensively studied during the last few decades – especially in human and bovine milks and some dairy products – very few publications on this topic are available, especially in other dairy species’ milk and their processed dairy products. Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep, horse, camel, and other minor species. Park has assembled a group of internationally reputed scientists in the forefront of functional milk and dairy products, food science and technology as contributors to this unique book. Coverage for each of the various dairy species includes: bioactive proteins and peptides; bioactive lipid components; oligosaccharides; growth factors; and other minor bioactive compounds, such as minerals, vitamins, hormones and nucleotides, etc. Bioactive components are discussed for manufactured dairy products, such as caseins, caseinates, and cheeses; yogurt products; koumiss and kefir; and whey products. Aimed at food scientists, food technologists, dairy manufacturers, nutritionists, nutraceutical and functional foods specialists, allergy specialists, biotechnologists, medical and health professionals, and upper level students and faculty in dairy and food sciences and nutrition, Bioactive Components in Milk and Dairy Products is an important resource for those who are seeking nutritional, health, and therapeutic values or product technology information on milk and dairy products from the dairy cow and species beyond. Areas featured are: • Unique coverage of bioactive compounds in milks of the dairy cow and minor species, including goat, sheep, buffalo, camel, and mare • Identifies bioactive components and their analytical isolation methods in manufactured dairy products , such as caseins, caseinates, and cheeses; yogurt products; koumiss and kefir; and whey products • Essential for professionals as well as biotechnology researchers specializing in functional foods, nu-traceuticals, probiotics, and prebiotics • Contributed chapters from a team of world-renowned expert scientists.

439 pgs.

Espinoza Rado, Erika Paola. “Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products Bioactive Components in Milk and Dairy Products,” n.d.